1. Emotion dysregulation as a transdiagnostic mechanism of ...
6 jun 2018 · Emotion dysregulation is an important and malleable treatment target with the potential to reduce or prevent opioid misuse and suicidality among opioid-treated ...
Chronic pain is a prevalent condition that causes functional impairment and emotional suffering. To allay pain-induced suffering, opioids are often prescribed for chronic pain management. Yet, chronic pain patients on opioid therapy are at heightened risk for opioid misuse—behaviors that can lead to addiction and overdose. Relatedly, chronic pain patients are at elevated risk for suicidal ideation and suicidal behaviors. Opioid misuse and suicidality are maladaptive processes aimed at alleviating the negative emotional hyperreactivity, hedonic hyporeactivity, and emotion dysregulation experienced by chronic pain patients on opioid therapy. In this review, we explore the role of emotion dysregulation in chronic pain. We then describe why emotionally dysregulated chronic pain patients are vulnerable to opioid misuse and suicidality in response to these negative affective states. Emotion dysregulation is an important and malleable treatment target with the potential to reduce or prevent opioid misuse and suicidality among opioid-treated chronic pain patients.
2. Opioid Warning Sticker and Patient Information Handout, and Risk ...
15 mrt 2019 · Information on required warning sticker and patient information handout for prescription opioid drugs.
Information on required warning sticker and patient information handout for prescription opioid drugs.
3. Stress-Induced Changes in the Endogenous Opioid System Cause ...
Endogenous opioid signaling is reportedly associated with analgesia, reward, addiction, and the regulation of stress responses and anxiety.
Early life stress, such as child abuse and neglect, and psychosocial stress in adulthood are risk factors for psychiatric disorders, including depression and anxiety. Furthermore, exposure to these stresses affects the sensitivity to pain stimuli and is associated with the development of chronic pain. However, the mechanisms underlying the pathogenesis of stress-induced depression, anxiety, and pain control remain unclear. Endogenous opioid signaling is reportedly associated with analgesia, reward, addiction, and the regulation of stress responses and anxiety. Stress alters the expression of various opioid receptors in the central nervous system and sensitivity to opioid receptor agonists and antagonists. μ-opioid receptor-deficient mice exhibit attachment disorders and autism-like behavioral expression patterns, while those with δ-opioid receptor deficiency exhibit anxiety-like behavior. In contrast, deficiency and antagonists of the κ-opioid receptor suppress the stress response. These findings strongly suggest that the expression and dysfunction of the endogenous opioid signaling pathways are involved in the pathogenesis of stress-induced psychiatric disorders and chronic pain. In this review, we summarize the latest basic and clinical research studies on the effects of endogenous opioid signaling on early-life stress, psychosocial stress-induced psychiatric disorders, and chronic pain.
4. Intrathecal morphine - Starship
23 nov 2023 · Morphine is a hydrophilic opioid that binds to opioid receptors in the CNS. When administered via the epidural or intrathecal (IT) route morphine diffuses ...
Date last published: 01 December 2024
5. [PDF] EMOTE: Emergency Mobile Opioid Treatment Everett
Medication for Opioid Use. Disorder (MOUD) is the best way to treat fentanyl addiction, but must overcome structural and emotional barriers to care. EMOTE ...
6. What Are Opioids? | NCDHHS
... emotion and breathing. Depending on how much you take and how you take them ... • Morphine (MS Contin®) • Codeine • Hydrocodone (Vicodin®, Norco ...
Opioids are a class of drugs used to reduce pain. Opioids include some prescription pain medications, synthetic fentanyl and heroin. All opioids have a
7. Dysregulation of Endogenous Opioid Emotion Regulation Circuitry in ...
Dysregulation of endogenous opioid emotion regulation circuitry in major depression in women. Susan E. Kennedy, PhD ; Robert A. Koeppe, PhD ; Elizabeth A. ...
Context There is extensive evidence implicating dysfunctions in stress responses and adaptation to stress in the pathophysiological mechanism of major depressive disorder (MDD) in humans. Endogenous opioid neurotransmission activating μ-opioid receptors is involved in stress and emotion...
8. Opioid Medicines – Part A: Opioid Warning Sticker - Canada.ca
2 mei 2018 · Opioid warning label to be distributed with prescription opioid drugs.
Opioid warning label to be distributed with prescription opioid drugs
9. Maternal psychophysiology profiles: associations with prenatal opioid ...
3 aug 2024 · Opioid use among pregnant women has more than quadrupled over the past 20 years; however, comorbid risk factors such as emotion ...
Opioid use among pregnant women has more than quadrupled over the past 20 years; however, comorbid risk factors such as emotion dysregulation confound the developmental consequences of prenatal opioid use. Maternal respiratory sinus arrhythmia (RSA) may help to disentangle the comorbid risk factors of prenatal emotion dysregulation and substance use and isolate their consequences on newborn neurobehavior. We examined maternal RSA in response to a mild, infant-related stress task in pregnant people (N = 192; 30 on medications for opioid use disorder) recruited from hospitals and a specialty prenatal clinic for substance use disorder. Three latent profiles emerged based on maternal RSA reactivity. Mothers with RSA increasing (Profile 3; more nervous system dysregulation) had higher levels of emotion dysregulation than mothers with RSA decreasing (Profile 1; well-regulated nervous system responses) but were not more likely to use opioids. Additionally, RSA profiles were associated with newborn neurobehavior, including attention, regulation, handling, and arousal. Given the variability in opioid use across RSA profiles and profile associations with newborn neurodevelopment, future studies should examine protective factors in pregnant individuals using opioids who show more flexible RSA responses.
10. NCORE: Neural Correlates of Reward and Emotion in opioid dependence
In this study, we are investigating the effects of opioid dependence on brain function, with the aim of improving treatment for detoxification and relapse ...
In this study, we are investigating the effects of opioid dependence on brain function, with the aim of improving treatment for detoxification and relapse prevention.
